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Pharmacological Reports 2010, 62, 1?14 ISSN 1734-1140 Copyright © 2010 by implant of Pharmacology Polish academy of Sciences Review Huntingtons disease: patho elementsis to wildcat(prenominal) models Puneet Kumar, Harikesh Kalonia, indigo Kumar Pharmacology Division, University Institute of pharmaceutic Sciences, UGC Centre of locomote Study, Panjab University, Chandigarh-160014, India rest: Anil Kumar e-mail: kumaruips@yahoo.com , pinch: Huntingtons disease (HD) is an catching genetic disorder, characterized by cognitive dysfunction and vicarious body movements called chorea. George Huntington, an Ohio physician, described the disease only in 1872. HD is a dominantly inherited disorder, characterized by progressive neurodegeneration of the striate body but as puff up involves other regions, primarily the cerebral cortex. The mutation responsible for this mysterious disease is an abnormally expand and unstable CAG repeat inwardly the coding region of the gene encoding the huntingtin protein. Various hypotheses occupy been put forward to rationalize the pathogenic mechanisms of mutant huntingtin-induced neural dysfunction and cell death. no(prenominal) of these hypotheses, however, offers a clear exposition; thus, it remains a issuance of research interest.

HD is considered to be an principal(prenominal) disease, embodying some of the major themes in advanced(a) neuroscience, including molecular genetics, discriminating neuronal vulnerability, excitotoxicity, mitochondrial dysfunction, apoptosis and transcriptional dysregulation. A morsel of recent reports brook cerebrate that oxidative stress plays a key eccentric in HD pathogenesis. Although thither is no specific treatment addressable to parry disease progression, treatments are useable to help in unconditional the chorea symptoms. As animal models are the scoop tools to judge any therapeutic agent, there are in extension different animal models available, mimicking a few or a larger number of symptoms. each model has its own advantages and limitations. The...If you ensure to get a ample essay, order it on our website: Ordercustompaper.com

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